SB 258719

Research use only, not for human use.

SB 258719 is a selective antagonist of 5-HT7 receptor with pKi of 7.5.

SB 258719 is a selective antagonist of 5-HT7 receptor with pKi of 7.5.(In Vitro):SB 258719 antagonised surmountably 5-CT-stimulated adenylyl cyclase activity. Schild analysis of the antagonism by SB 258719 gave a pA2?of 7.2±0.2 and slope not significantly different from 1, consistent with competitive antagonism.(In Vivo):SB 258719 (5-20 mg/kg, i.p.) reversed the hypothermic effect of 5-CT in mice. Increased Wnt/β-catenin activity was attenuated by SB 258719 in HCC cell lines and patient-derived primary tumour tissues in the presence of 5-HT. SB 258719 also reduced tumour growth in vivo.

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Endocrinology/Hormones

5-HT Receptor

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195199-95-2

338.5

C18H30N2O2S

>98% (HPLC)

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C[C@H](CCN1CCC(C)CC1)N(C)S(=O)(=O)c1cccc(C)c1

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(-20℃)

With Ice Pack

≥ 2 years